What you just have to do is make your organism do all the work for you. Pay attention: if you want a routine that will take less than 5 minutes per day, just try gooogling Simmy Krotiel's homepage and good luck. 2-4 in . longer might not be much, yet certainly feasible.
What you just have to do is make your organism do all the work for you. Pay attention: if you want a routine that will take less than 5 minutes per day, just try gooogling Simmy Krotiel's homepage and good luck. 2-4 in . longer might not be much, yet certainly feasible.
I think you should publish a book "Longevity and how to obtain it". Your knowledge is outstanding. Publish on Audio Books so I can listen as I go to sleep...great work.
Thank you ✨❤️✨
Wicked Smaht !!!
If we should be hindering DNA methylation as Dr Kennedy stated in regard to the AKG results, then if we take TMG to prevent methylation deficiency when we take niacin or NMN, then could we have excess methylation activity if we overshoot? https://www.longevity.technology/age-of-resistance-as-clever-supplement-holds-back-biological-aging/
I'm getting conflicting information, so the ref above from the Dr. Kennedy Lab shows AKG inhibits TOR, but I saw another study showing the opposite,"low-protein diets supplemented with AKG enhanced serum and intramuscular free AA concentrations, the mRNA abundances of AA transporters, and serum concentrations of insulin-like growth factor-1 (IGF-1), activated the mammalian target of rapamycin (mTOR) pathway" (doi: 10.1007/s00726-018-2618-3.). It seems contradictory that AKG would facilitate lifespan extension since it activates mTOR which shortens lifespan, though it enhances tissue repair, muscle growth, etc. , an effect similar to branched chain amino acids. These are at odds with lifespan extension though one can argue it helps with healthspan improvement, but at a possible cost for increased lifespan? Can someone explain this? here's anotehr study showing AKG mTOR effects: J Nutr . 2016 Aug;146(8):1514-20. doi: 10.3945/jn.116.236000. Epub 2016 Jul 6. Dietary Supplementation with α-Ketoglutarate Activates mTOR Signaling and Enhances Energy Status in Skeletal Muscle of Lipopolysaccharide-Challenged Piglets Lei Wang 1, Dan Yi 1, Yongqing Hou 2, Binying Ding 1, Kang Li 1, Baocheng Li 1, Huiling Zhu 1, Yulan Liu 1, Guoyao Wu 3
Actually, the same health improvement can be achieved for peanuts by taking more than 2 g of citric acid or any citrate per day. AKG can be produced in our body from citrates.
And indeed, if to use citric acid with meat, the advantage will be better protein digestion. Or with water - it also will help but in lesser extent.
Can AAKG have same effect?
From my understanding those inflammatory markers are secreted by senescent cells to signal our body to get rid of it. Wouldn't the suppression of this secretion caused by AKG supplementation cause a net accumulation of senescent cells theoretically?
Too many...
I'm concerned about the glutamine-generating aspect of AKG. Could it contribute to cancer growth?
Also, there's this: "... enhanced GLN [glutamine] synthesis may exert adverse effects in the brain (swelling
of astrocytes or altered neurotransmission) and stimulate catabolism of
branched-chain amino acids (BCAA; valine, leucine, and isoleucine) in
skeletal muscle. Furthermore, the majority of GLN produced is released
to the blood and catabolized in enterocytes and the kidneys to ammonia,
which due to liver injury escapes detoxification to urea and appears in
peripheral blood. As only one molecule of ammonia is detoxified in GLN
synthesis whereas two molecules may appear in GLN breakdown, these
events can be seen as a vicious cycle in which enhanced ammonia
concentration activates synthesis of GLN leading to its subsequent
catabolism and increase in ammonia levels in the blood."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930847/
What did the mice die of, exactly?
Thanks Eleanor! This video is so well made! nice and simple! By the way I am the first author of the paper!
Wrong information. Ca form is unavailable to anyone except research scientists. It has not been used in humans, only lab rats. Use caution. It's dangerous for humans as far as we know.
Shut up and tell me where to buy this CaAKG!
Is there a big difference between the effect of Ca-AKG and AAKG?
Which form is more effective? Glutamine-AKG or Arginine-AKG?
Hey so where can I buy it in the correct form? I can find it as ornithine and Argentine but not as a calcium salt as was used in the experiment!
hey Eleanor, I wonder: every time some lab discover something new, you guys that are already in the field are something like in the VIP area, what means you people in this biomedical field are always 100 steps forward compared to us mere mortals, that live in the dark.
But how much of newspapers in the aging field really affect how you live? I think I saw somewhere that you already take some supplements related to aging healthier, but I don't remember where. I know it's very personal but does be in the field really gives you an advantage compared to people in other areas, or new discoveries don't affect your life at all, maybe because you don't care? Do you see any difference in healthy and aging compared to people around you? Not being rude, its pure curiosity. And that is not the time to be modest, .
Would you recommend taking the Calcium-AKG in capsule form as in the rejuvenate capsules or directly in powder form? Which do you think would be better?
hey sheekey, have you decided what you want to do in life, I mean, what you will specialize him?
Wow, really great video explaining the study. Thanks for making it!
Thanks for watching!
Make sure to check out this video's description to see my full supplement stack
AAKG ativates mtor which might defeat its use as a longevity supplement, would love to see a follow up video on Calcium AKG
I’d be interested in you diet sir
Hbot is the answer. Together with healthy ketosis or carnivore, time restricted feeding , good sleep , hiit, and some suplements ( krill oil, astanxantin, d3, k2, magnessium, nutritional yeast, sauerkraut) and finally do not stress! Smile !
What about inositol stabilized l argenine
That's why I felt good and younger when I took it: Arginin Alpha Ketoglutarat +Ornithin Alpha Ketoglutarat🤔🏋️♂️🍀
Please let us know in details how you do your intermittence fasting?
Double Wood Supplements AKG (not AAKG)
Found a company called Klaire Labs that sells an AKG supplement. I don't know much about them though. I put their name is come sites that test products but nothing turned up. Great video, thanks.
The Krebs cycle does not burn fats
TET enzymes catalyze DNA DEmethylation not methylation!!!
Mmm I should wait for further information. There are already several good options available.
Been using AKG in the treatment of Autism, helps to resolve ammonia a by-product of making ATP in the the kreb cycle thereby improving energy in the cell, so not surprised.
Does the sugar in honey outweigh its benefits?
Is there a way to measure AKG before and after doing the fasting and keto interventions?
In the future can you review the anti-aging compounds discovered by Vladimir Titorenko at Concordia University in Canada? I make a liposomal formula with 7 of them and report the details at this video:
https://www.youtube.com/watch?v=Y9GOX32PZxE&t=2069s
The part showing how to make the formula begins at 33:25 and there is no promotion or advertising at my videos.
I did a water fast for 4 days, and to be honest, it was truly awful. However, the after effect was pure bliss.
It looks like we need a protocol for an AKG promoting diet like the fasting directions. Something like how many times we should do a ketogenic diet in a year and for how long...
How does something decline by "10 times"? If I have a liter of water, and it declines by "10 times", I would have -9 liters of water. Sorry, but your math makes no sense.
I can only find AAKG is this the same thing? thanks
What a great video. I am going to try AKG. It has muscle building properties also.
Once again proving that Jeff has zero idea how the two work on the body and why . Keep your day job stud. You have zero idea what the hell your talking about . Your Google education failed you again.
Good info! BUT PLEASE SLOW DOWN!!!!!!
6g of citrulin a day?
How long does it take for your blood vessels to dilate
Really informative vid I take combo of this with l-lysine and l-ornithine xx
Much appreciate this Jeff. Great explanation
Feed Me More's "Wake Up!" brand pre workout haves both Citruline Malate & Arginine. Guess they were like "Which should we use?" and they be like "Guess what? F*** it! Put in both!"
Can you make a video on SARM?
If I only take l-citrulline malate with 6 to 8 g per day, I don't need to take l-arginine too? I am 58 years old and I do bodybuilding
Should make mention that acetylcholine starts the whole process. So you should take a form of choline in your preworkout
3 shots of jack Daniel's 15-20 minutes before workout will do the work
I'm using Acetyl L-Carnitine as pre-workout suppliment. I'm working out in fasted state in the morning. I'm looking to shred some fat around my belly. Can I combine Citrulline Malate with L-Carnitine b4 workout?
Anyone taking l norveline? I heard it works very well but it might do damage to the brain. Is it ok to take small doses for short period of time?
Aygna to to eggsplain
Jeff: How long Before Training and what dose?
Can u take citruline and arginine together?
But is that the same for AKKG?
Next make a video about ingredient break-down on pre workouts
Methamphetamine vs Adderall
6 to 8 grams with how much water? eight ounces of water or less? Thank..
This guy is the GOAT